The study was conducted using a hospital-based cross-sectional method, and data were obtained from psychiatric patients with COVID-19 who were admitted to the COVID-19 treatment wards of the National Center for Mental Health from April 22 to July 1, 2022, using a 126-item questionnaire that was classified into 4 sections. The study covered 39 (48.8%) men, 41 (51.3%) women aged 22-71 years, and a total of 80 psychiatric patients with COVID-19, and the average age was 44.5 ± 12.5. According to the severity of Covid-19 disease, 26.3% had no clinical signs, 43.8% had mild, 28.8% had moderate, and 1.3% had more severe clinical signs. In the study of adherence to the treatment regimen, patients with mental retardation and schizophrenia could not adhere to the treatment regimen with the support of medical staff. Although participants with alcoholism had severe form of Covid-19, 40.0% of patients with schizophrenia, 33.3% of patients with schizophrenic spectrum disorders, 36.4% of people with organic dementia, and 15.4% of people mental retardation had a mild form of Covid-19. Patients with mental retardation and schizophrenia were unable to follow the treatment regimen of Covid-19 on their own.